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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PTGS2 Antibody (Center P378) Blocking peptide   

PTGS2 Antibody (Center P378) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P35354
Clone Names 80612113
Peptide ID 80612113
Additional Information
Gene ID 5743
Other Names Prostaglandin G/H synthase 2, Cyclooxygenase-2, COX-2, PHS II, Prostaglandin H2 synthase 2, PGH synthase 2, PGHS-2, Prostaglandin-endoperoxide synthase 2, PTGS2, COX2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PTGS2
Synonyms COX2
Function Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Cellular Location Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein
Research Areas
Citations (0)

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Prostaglandin-endoperoxide synthase (PTGS), also known ascyclooxygenase, is the key enzyme in prostaglandin biosynthesis,and acts both as a dioxygenase and as a peroxidase. There are twoisozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2,which differ in their regulation of expression and tissuedistribution. This gene encodes the inducible isozyme. It isregulated by specific stimulatory events, suggesting that it isresponsible for the prostanoid biosynthesis involved ininflammation and mitogenesis.


Duggan, K.C., et al. J. Biol. Chem. 285(45):34950-34959(2010)Feher, A., et al. Am J Geriatr Psychiatry 18(11):983-987(2010)Wang, C.H., et al. Anticancer Res. 30(9):3649-3653(2010)Han, E.H., et al. J. Toxicol. Environ. Health Part A 73 (21-22), 1451-1464 (2010) :Cao, H., et al. Tohoku J. Exp. Med. 222(1):15-21(2010)

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$ 80.00
Cat# BP11553c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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