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HBB Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P68871 |
|---|---|
| Clone Names | 80902109 |
| Gene ID | 3043 |
|---|---|
| Other Names | Hemoglobin subunit beta, Beta-globin, Hemoglobin beta chain, LVV-hemorphin-7, Spinorphin, HBB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HBB |
|---|---|
| Function | Involved in oxygen transport from the lung to the various peripheral tissues. [Spinorphin]: Functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and as a selective antagonist of the P2RX3 receptor which is involved in pain signaling, these properties implicate it as a regulator of pain and inflammation. |
| Tissue Location | Red blood cells.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The alpha (HBA) and beta (HBB) loci determine thestructure of the 2 types of polypeptide chains in adult hemoglobin,Hb A. The normal adult hemoglobin tetramer consists of two alphachains and two beta chains. Mutant beta globin causes sickle cellanemia. Absence of beta chain causes beta-zero-thalassemia. Reducedamounts of detectable beta globin causes beta-plus-thalassemia. Theorder of the genes in the beta-globin cluster is 5'-epsilon --gamma-G -- gamma-A -- delta -- beta--3'.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)Onakoya, P.A., et al. Ear Nose Throat J 89(7):306-310(2010)Belisario, A.R., et al. Acta Haematol. 124(3):162-170(2010)Prakobkaew, N., et al. Acta Haematol. 124(2):115-119(2010)
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