SASH1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O94885 |
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Clone Names | 80703042 |
Gene ID | 23328 |
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Other Names | SAM and SH3 domain-containing protein 1, Proline-glutamate repeat-containing protein, SASH1, KIAA0790, PEPE1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SASH1 |
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Synonyms | KIAA0790, PEPE1 |
Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). |
Cellular Location | Cytoplasm. |
Tissue Location | Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes (PubMed:23333244, PubMed:26203640). |
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Provided below are standard protocols that you may find useful for product applications.
Background
SASH1 may have a role in a signaling pathway and could act as a tumor suppressor.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Heinzen, E.L., et al. J. Alzheimers Dis. (2009) In press :
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