|Other Names||Sciellin, SCEL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in the assembly or regulation of proteins in the cornified envelope. The LIM domain may be involved in homotypic or heterotypic associations and may function to localize sciellin to the cornified envelope.|
|Cellular Location||Cytoplasm. Membrane. Note=May become cross- linked to membrane proteins by transglutaminase|
|Tissue Location||Highly expressed in esophagus. It is also expressed in keratinocytes, amniotic tissue, foreskin stratum spinosum and stratum granulosum, hair follicle and nail|
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The protein encoded by this gene is a precursor to thecornified envelope of terminally differentiated keratinocytes. Thisprotein localizes to the periphery of cells and may function in theassembly or regulation of proteins in the cornified envelope.Transcript variants encoding different isoforms exist. A transcriptvariant utilizing an alternative polyA signal has been described inthe literature, but its full-length nature has not been determined.
Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) :Corona, W., et al. Anticancer Res. 24 (3A), 1417-1419 (2004) :Champliaud, M.F., et al. J. Invest. Dermatol. 121(4):781-785(2003)Champliaud, M.F., et al. Genomics 70(2):264-268(2000)Champliaud, M.F., et al. J. Biol. Chem. 273(47):31547-31554(1998)
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