OPN-a/b Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P10451 |
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Clone Names | 80722113 |
Gene ID | 6696 |
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Other Names | Osteopontin, Bone sialoprotein 1, Nephropontin, Secreted phosphoprotein 1, SPP-1, Urinary stone protein, Uropontin, SPP1, BNSP, OPN |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SPP1 |
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Synonyms | BNSP, OPN |
Function | Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. |
Cellular Location | Secreted |
Tissue Location | Detected in cerebrospinal fluid and urine (at protein level) (PubMed:25326458, PubMed:36213313, PubMed:37453717) Bone. Found in plasma. |
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Background
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity).
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Weber, G.F., et al. Br. J. Cancer 103(6):861-869(2010)Chen, R.X., et al. J. Gastroenterol. Hepatol. 25(8):1435-1442(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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