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GUCY2D Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q02846 |
|---|---|
| Clone Names | 80513173 |
| Gene ID | 3000 |
|---|---|
| Other Names | Retinal guanylyl cyclase 1, RETGC-1, Guanylate cyclase 2D, retinal, Rod outer segment membrane guanylate cyclase, ROS-GC, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GUCY2D |
|---|---|
| Function | Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21928830, PubMed:30319355, PubMed:26100624, PubMed:9600905, PubMed:15123990). May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane (By similarity). |
| Cellular Location | Photoreceptor outer segment membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein |
| Tissue Location | Retina.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a retina-specific guanylate cyclase,which is a member of the membrane guanylyl cyclase family. Likeother membrane guanylyl cyclases, this enzyme has a hydrophobicamino-terminal signal sequence followed by a large extracellulardomain, a single membrane spanning domain, a kinase homologydomain, and a guanylyl cyclase catalytic domain. In contrast toother membrane guanylyl cyclases, this enzyme is not activated bynatriuretic peptides. Mutations in this gene result in Lebercongenital amaurosis and cone-rod dystrophy-6 diseases. [providedby RefSeq].
References
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Pasadhika, S., et al. Invest. Ophthalmol. Vis. Sci. 51(5):2608-2614(2010)Sundaresan, P., et al. Mol. Vis. 15, 1781-1787 (2009) :
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