|Other Names||Secreted frizzled-related protein 4, sFRP-4, Frizzled protein, human endometrium, FrpHE, SFRP4, FRPHE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (By similarity). SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (PubMed:12952927).|
|Cellular Location||Secreted. Note=Cytoplasmic in ovarian tumor cells|
|Tissue Location||Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level)|
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Secreted frizzled-related protein 4 (SFRP4) is a member ofthe SFRP family that contains a cysteine-rich domain homologous tothe putative Wnt-binding site of Frizzled proteins. SFRPs act assoluble modulators of Wnt signaling. The expression of SFRP4 inventricular myocardium correlates with apoptosis related geneexpression.
Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)Kohno, H., et al. Oncol. Rep. 24(2):423-431(2010)Frank, B., et al. Carcinogenesis 31(8):1381-1386(2010)Huang, D., et al. J. Cancer Res. Clin. Oncol. 136(3):395-401(2010)Hirata, H., et al. Cancer 115(19):4488-4503(2009)
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