|Other Names||Sortilin, 100 kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, NTR3, SORT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.|
|Cellular Location||Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein Golgi apparatus, Golgi stack membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane; Single-pass type I membrane protein. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin|
|Tissue Location||Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver|
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This gene encodes a protein that is a multi-ligand type-1receptor with similarity to the yeast carboxypeptidase Y sortingreceptor Vps10 protein. The encoded protein, a trans-Golgi network(TGN) transmembrane protein, binds a number of unrelated ligandsthat participate in a wide range of cellular processes; however, itlacks the typical features of a signalling receptor. In the TGN,furin mediates the activation of the mature binding form. Theencoded protein consists of a large luminal domain, a singletransmembrane segment and short C-terminal cytoplasmic tail. Theluminal domain contains a cysteine-rich region similar to twocorresponding segments in the yeast Vps10p; the cytoplasmic tail issimilar to the corresponding segment of the cation-independentmannose 6-phosphate receptor and the tail also interacts with theVHS domains of GGA (Golgi-associated, gamma-adaptin homologous,ARF-interacting) proteins.
Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Kjolby, M., et al. Cell Metab. 12(3):213-223(2010)Musunuru, K., et al. Nature 466(7307):714-719(2010)Teslovich, T.M., et al. Nature 466(7307):707-713(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
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