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CLEC12B Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q2HXU8
Clone Names 100111305
Additional Information
Gene ID 387837
Other Names C-type lectin domain family 12 member B, Macrophage antigen H, CLEC12B
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC12B {ECO:0000303|PubMed:34310951, ECO:0000312|HGNC:HGNC:31966}
Function Inhibitory receptor postulated to negatively regulate immune and non-immune functions (PubMed:17562706, PubMed:34310951). Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals (PubMed:17562706, PubMed:34310951). Although it inhibits KLRK1/NKG2D- mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart (PubMed:17562706). May limit activation of myeloid cell subsets in response to infection or tissue inflammation (PubMed:17562706). May protect target cells against natural killer cell-mediated lysis (PubMed:17562706). May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3 (PubMed:34310951).
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Detected in colon, heart, kidney, liver, lung, mammary gland, ovary, spleen and testis (PubMed:17562706). Expressed in melanocytes (at protein level) (PubMed:34310951)
Research Areas
Citations (0)
citation

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Background

Cell surface receptor that protects target cells against natural killer cell-mediated lysis. Modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.

References

Hoffmann, S.C., et al. J. Biol. Chem. 282(31):22370-22375(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 277.78
Cat# BP11585b
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