|Other Names||SOSS complex subunit B1, Nucleic acid-binding protein 2, Oligonucleotide/oligosaccharide-binding fold-containing protein 2B, Sensor of single-strand DNA complex subunit B1, Sensor of ssDNA subunit B1, SOSS-B1, Single-stranded DNA-binding protein 1, hSSB1, NABP2, OBFC2B, SSB1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.|
|Cellular Location||Nucleus Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment|
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Provided below are standard protocols that you may find useful for product applications.
Single-stranded DNA (ssDNA)-binding proteins, such asOBFC2B, are ubiquitous and essential for a variety of DNA metabolicprocesses, including replication, recombination, and detection andrepair of damage (Richard et al., 2008 [PubMed 18449195]).[suppliedby OMIM].
Skaar, J.R., et al. J. Cell Biol. 187(1):25-32(2009)Li, Y., et al. J. Biol. Chem. 284(35):23525-23531(2009)Huang, J., et al. Mol. Cell 35(3):384-393(2009)Richard, D.J., et al. Nature 453(7195):677-681(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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