|Other Names||2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Ceramide UDP-galactosyltransferase, Cerebroside synthase, UDP-galactose-ceramide galactosyltransferase, UGT8, CGT, UGT4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.|
|Cellular Location||Membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Galactocerebrosides are abundant sphingolipids of themyelin membrane of the central nervous system and peripheralnervous system and are also present in small amounts in kidney. Thekey enzymatic step in the biosynthesis of galactocerebrosidesconsists of the transfer of galactose to ceramide catalyzed byUDP-galactose ceramide galactosyltransferase (CGT, EC 22.214.171.124).The enzyme encoded by the CGT gene is the first involved in complexlipid biosynthesis in the myelinating oligodendrocyte.[supplied byOMIM].
Dziecedil Giel, P., et al. Br. J. Cancer 103(4):524-531(2010)Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)Ruckhaberle, E., et al. J. Cancer Res. Clin. Oncol. 135(8):1005-1013(2009)Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
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