|Other Names||Leukocyte immunoglobulin-like receptor subfamily A member 5, CD85 antigen-like family member F, Immunoglobulin-like transcript 11, ILT-11, Leukocyte immunoglobulin-like receptor 9, LIR-9, CD85f, LILRA5, ILT11, LILRB7, LIR9|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ILT11, LILRB7, LIR9|
|Function||May play a role in triggering innate immune responses. Does not seem to play a role for any class I MHC antigen recognition.|
|Cellular Location||Isoform 1: Membrane; Single-pass type I membrane protein. Secreted Isoform 3: Secreted.|
|Tissue Location||Expressed mostly in tissues of the hematopoietic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells or natural killer (NK) cells (at protein level).|
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The protein encoded by this gene is a member of theleukocyte immunoglobulin-like receptor (LIR) family. LIR familymembers are known to have activating and inibitory functions inleukocytes. Crosslink of this receptor protein on the surface ofmonocytes has been shown to induce calcium flux and secretion ofseveral proinflammatory cytokines, which suggests the roles of thisprotein in triggering innate immune responses. This gene is one ofthe leukocyte receptor genes that form a gene cluster on thechromosomal region 19q13.4. Four alternatively spliced transcriptvariants encoding distinct isoforms have been described. [providedby RefSeq].
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)Shiroishi, M., et al. J. Biol. Chem. 281(28):19536-19544(2006)Borges, L., et al. Blood 101(4):1484-1486(2003)Wende, H., et al. Immunogenetics 51 (8-9), 703-713 (2000) :
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