|Other Names||Host cell factor C1 regulator 1, HCF-1 beta-propeller-interacting protein, HCFC1R1, HPIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.|
|Cellular Location||Cytoplasm. Nucleus. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner|
|Tissue Location||Widely expressed. EMBL; AY116892; AAM49798.1; -; mRNA EMBL; AK000575; BAA91265.1; -; mRNA EMBL; CR457245; CAG33526.1; -; mRNA EMBL; CH471112; EAW85425.1; -; Genomic_DNA EMBL; CH471112; EAW85426.1; -; Genomic_DNA EMBL; BC064026; AAH64026.1; -; mRNA EMBL; BC080178; AAH80178.1; -; mRNA CCDS; CCDS10490.1; -. [Q9NWW0-1] CCDS; CCDS32375.1; -. [Q9NWW0-2] RefSeq; NP_001002017.1; NM_001002017.2. [Q9NWW0-2] RefSeq; NP_001002018.1; NM_001002018.2. [Q9NWW0-1] RefSeq; NP_001275594.1; NM_001288665.1. [Q9NWW0-1] RefSeq; NP_001275595.1; NM_001288666.1. [Q9NWW0-2] RefSeq; NP_001275596.1; NM_001288667.1 RefSeq; NP_001275597.1; NM_001288668.1 RefSeq; NP_060355.1; NM_017885.3. [Q9NWW0-1] UniGene; Hs.423103; - ProteinModelPortal; Q9NWW0; - BioGrid; 120320; 3 IntAct; Q9NWW0; 1 MINT; MINT-1424323; - iPTMnet; Q9NWW0; - PhosphoSitePlus; Q9NWW0; - BioMuta; HCFC1R1; - PaxDb; Q9NWW0; - PRIDE; Q9NWW0; - DNASU; 54985; - Ensembl; ENST00000248089; ENSP00000248089; ENSG00000103145. [Q9NWW0-1] Ensembl; ENST00000574151; ENSP00000459178; ENSG00000103145. [Q9NWW0-2] Ensembl; ENST00000574980; ENSP00000460639; ENSG00000103145. [Q9NWW0-1] GeneID; 54985; - KEGG; hsa:54985; - UCSC; uc002csy.3; human. [Q9NWW0-1] CTD; 54985; - GeneCards; HCFC1R1; - HGNC; HGNC:21198; HCFC1R1 HPA; HPA059647; - neXtProt; NX_Q9NWW0; - OpenTargets; ENSG00000103145; - PharmGKB; PA134951485; - eggNOG; ENOG410IZTH; Eukaryota eggNOG; ENOG4111EF3; LUCA GeneTree; ENSGT00390000015785; - HOGENOM; HOG000112942; - HOVERGEN; HBG107981; - InParanoid; Q9NWW0; - OrthoDB; EOG091G0VZ8; - PhylomeDB; Q9NWW0; - TreeFam; TF338381; - BioCyc; ZFISH:ENSG00000103145-MONOMER; - ChiTaRS; HCFC1R1; human GenomeRNAi; 54985; - PRO; PR:Q9NWW0; - Proteomes; UP000005640; Chromosome 16 Bgee; ENSG00000103145; - CleanEx; HS_HCFC1R1; - ExpressionAtlas; Q9NWW0; baseline and differential Genevisible; Q9NWW0; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell InterPro; IPR029195; HCFC1R1 Pfam; PF15226; HPIP; 1 1: Evidence at protein level; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome CHAIN 1 138 Host cell factor C1 regulator 1 /FTId=PRO_0000338978 REGION 76 79 Interaction with HCFC1 MOTIF 110 119 Nuclear export signal VAR_SEQ 32 51 SSPLRGAVPMSTKRRLEEEQ -> R (in isoform 2) /FTId=VSP_034082 VARIANT 92 92 P -> Q (in dbSNP:rs10508) /FTId=VAR_043849 MUTAGEN 76 79 DHPY->AAPA: Loss of interaction with HCFC1. MUTAGEN 117 119 LRL->ARA: Reduces nuclear export SEQUENCE 138 AA; 15291 MW; 34A9A04735276A16 CRC64; MILQQPLQRG PQGGAQRLPR AALGVTWGLD ASSPLRGAVP MSTKRRLEEE QEPLRKQFLS EENMATHFSQ LSLHNDHPYC SPPMTFSPAL PPLRSPCSEL LLWRYPGSLI PEALRLLRLG DTPSPPYPAT PAGDIMEL|
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Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Mahajan, S.S., et al. J. Biol. Chem. 277(46):44292-44299(2002)
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