|Other Names||Testisin, 3421-, Eosinophil serine protease 1, ESP-1, Serine protease 21, PRSS21, ESP1, TEST1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Could regulate proteolytic events associated with testicular germ cell maturation.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
|Tissue Location||Expressed predominantly in premeiotic testicular germ cells, mostly late pachytene and diplotene spermatocytes|
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This gene encodes a cell-surface anchored serine protease,which is a member of the trypsin family of serine proteases. It ispredicted to be active on peptide linkages involving the carboxylgroup of lysine or arginine. The protein localizes to the cytoplasmand the plasma membrane of premeiotic testicular germ cells and itmay be involved in progression of testicular tumors of germ cellorigin. Alternative splicing of this gene results in threetranscript variants encoding three different isoforms. [provided byRefSeq].
Yeom, S.Y., et al. FEBS Lett. 584(8):1469-1475(2010)Netzel-Arnett, S., et al. Biol. Reprod. 81(5):921-932(2009)Kempkensteffen, C., et al. J. Cancer Res. Clin. Oncol. 132(12):765-770(2006)Manton, K.J., et al. Br. J. Cancer 92(4):760-769(2005)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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