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PLAG1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6DJT9
Clone Names 101008228
Additional Information
Gene ID 5324
Other Names Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein, PLAG1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PLAG1
Function Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia.
Cellular Location Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited
Tissue Location Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors.
Research Areas
Citations (0)
citation

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Background

Pleomorphic adenoma gene 1 encodes a zinc finger proteinwith 2 putative nuclear localization signals. PLAG1, which isdevelopmentally regulated, has been shown to be consistentlyrearranged in pleomorphic adenomas of the salivary glands. PLAG1 isactivated by the reciprocal chromosomal translocations involving8q12 in a subset of salivary gland pleomorphic adenomas. Threetranscript variants encoding two different isoforms have been foundfor this gene.

References

Patz, M., et al. Leuk. Lymphoma 51(8):1379-1381(2010)Declercq, J., et al. Diabetes 59(8):1957-1965(2010)Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :

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$ 277.78
Cat# BP11647a
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