PLAG1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6DJT9 |
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Clone Names | 101008228 |
Gene ID | 5324 |
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Other Names | Zinc finger protein PLAG1, Pleiomorphic adenoma gene 1 protein, PLAG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLAG1 |
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Function | Transcription factor whose activation results in up- regulation of target genes, such as IGFII, leading to uncontrolled cell proliferation: when overexpressed in cultured cells, higher proliferation rate and transformation are observed. Other target genes such as CRLF1, CRABP2, CRIP2, PIGF are strongly induced in cells with PLAG1 induction. Proto-oncogene whose ectopic expression can trigger the development of pleomorphic adenomas of the salivary gland and lipoblastomas. Overexpression is associated with up-regulation of IGFII, is frequently observed in hepatoblastoma, common primary liver tumor in childhood. Cooperates with CBFB-MYH11, a fusion gene important for myeloid leukemia. |
Cellular Location | Nucleus. Note=Strong nucleolar localization when sumoylation is inhibited |
Tissue Location | Expressed in fetal tissues such as lung, liver and kidney. Not detected or weak detection in normal adult tissues, but highly expressed in salivary gland with benign or malignant pleiomorphic adenomas with or without 8q12 aberrations, with preferential occurrence in benign tumors. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pleomorphic adenoma gene 1 encodes a zinc finger proteinwith 2 putative nuclear localization signals. PLAG1, which isdevelopmentally regulated, has been shown to be consistentlyrearranged in pleomorphic adenomas of the salivary glands. PLAG1 isactivated by the reciprocal chromosomal translocations involving8q12 in a subset of salivary gland pleomorphic adenomas. Threetranscript variants encoding two different isoforms have been foundfor this gene.
References
Patz, M., et al. Leuk. Lymphoma 51(8):1379-1381(2010)Declercq, J., et al. Diabetes 59(8):1957-1965(2010)Okada, Y., et al. Hum. Mol. Genet. 19(11):2303-2312(2010)Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
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