|Other Names||Dickkopf-related protein 4, Dickkopf-4, Dkk-4, hDkk-4, Dickkopf-related protein 4 short form, DKK4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).|
|Tissue Location||Expressed in cerebellum, T-cells, esophagus and lung|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is a member of thedickkopf family. The secreted protein contains two cysteine richregions and is involved in embryonic development through itsinteractions with the Wnt signaling pathway. Activity of thisprotein is modulated by binding to the Wnt co-receptor and theco-factor kremen 2.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Hirata, H., et al. Cancer 115(19):4488-4503(2009)Matsui, A., et al. Cancer Sci. 100(10):1923-1930(2009)Baehs, S., et al. Cancer Lett. 276(2):152-159(2009)
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