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ADA Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P00813
Clone Names 101008261
Peptide ID 101008261
Additional Information
Gene ID 100
Other Names Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADA
Synonyms ADA1
Function Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine (PubMed:8452534, PubMed:16670267). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity).
Cellular Location Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958} Cytoplasm. Lysosome Note=Colocalized with DPP4 at the cell surface
Tissue Location Found in all tissues, occurs in large amounts in T-lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues
Research Areas
Citations (0)

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Background

This gene encodes an enzyme that catalyzes the hydrolysisof adenosine to inosine. Various mutations have been described forthis gene and have been linked to human diseases. Deficiency inthis enzyme causes a form of severe combined immunodeficiencydisease (SCID), in which there is dysfunction of both B and Tlymphocytes with impaired cellular immunity and decreasedproduction of immunoglobulins, whereas elevated levels of thisenzyme have been associated with congenital hemolytic anemia.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gloria-Bottini, F., et al. Am. J. Med. Sci. 340(2):103-108(2010)Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Spina, C., et al. Cancer Invest. (2010) In press :Ri, G., et al. Anticancer Res. 30(6):2347-2349(2010)

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$ 80.00
Cat# BP11650b
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