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ADA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00813 |
|---|---|
| Clone Names | 101008261 |
| Gene ID | 100 |
|---|---|
| Other Names | Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ADA |
|---|---|
| Synonyms | ADA1 |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine (PubMed:8452534, PubMed:16670267, PubMed:23193172, PubMed:9361033, PubMed:26166670). Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (PubMed:20959412). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (PubMed:11772392). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (PubMed:20959412). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (PubMed:23193172). Stimulates plasminogen activation (PubMed:15016824). Plays a role in male fertility (PubMed:21919946, PubMed:26166670). Plays a protective role in early postimplantation embryonic development (By similarity). |
| Cellular Location | Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P03958}. Cytoplasm. Lysosome. Note=Colocalized with DPP4 at the cell surface. |
| Tissue Location | Found in all tissues, occurs in large amounts in T- lymphocytes (PubMed:20959412). Expressed at the time of weaning in gastrointestinal tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme that catalyzes the hydrolysisof adenosine to inosine. Various mutations have been described forthis gene and have been linked to human diseases. Deficiency inthis enzyme causes a form of severe combined immunodeficiencydisease (SCID), in which there is dysfunction of both B and Tlymphocytes with impaired cellular immunity and decreasedproduction of immunoglobulins, whereas elevated levels of thisenzyme have been associated with congenital hemolytic anemia.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gloria-Bottini, F., et al. Am. J. Med. Sci. 340(2):103-108(2010)Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Spina, C., et al. Cancer Invest. (2010) In press :Ri, G., et al. Anticancer Res. 30(6):2347-2349(2010)
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