|Other Names||Adenosine deaminase, Adenosine aminohydrolase, ADA, ADA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte- epithelial cell adhesion.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Extracellular side. Cell junction. Cytoplasmic vesicle lumen. Cytoplasm. Note=Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion|
|Tissue Location||Found in all tissues, occurs in large amounts in T-lymphocytes and, at the time of weaning, in gastrointestinal tissues|
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This gene encodes an enzyme that catalyzes the hydrolysisof adenosine to inosine. Various mutations have been described forthis gene and have been linked to human diseases. Deficiency inthis enzyme causes a form of severe combined immunodeficiencydisease (SCID), in which there is dysfunction of both B and Tlymphocytes with impaired cellular immunity and decreasedproduction of immunoglobulins, whereas elevated levels of thisenzyme have been associated with congenital hemolytic anemia.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Gloria-Bottini, F., et al. Am. J. Med. Sci. 340(2):103-108(2010)Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Spina, C., et al. Cancer Invest. (2010) In press :Ri, G., et al. Anticancer Res. 30(6):2347-2349(2010)
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