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EFNB2 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P52799
Clone Names 100427280
Peptide ID 100427280
Additional Information
Gene ID 1948
Other Names Ephrin-B2, EPH-related receptor tyrosine kinase ligand 5, LERK-5, HTK ligand, HTK-L, EFNB2, EPLG5, HTKL, LERK5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EFNB2
Synonyms EPLG5, HTKL, LERK5
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Lung and kidney.
Research Areas
Citations (0)

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This gene encodes a member of the ephrin (EPH) family. Theephrins and EPH-related receptors comprise the largest subfamily ofreceptor protein-tyrosine kinases and have been implicated inmediating developmental events, especially in the nervous systemand in erythropoiesis. Based on their structures and sequencerelationships, ephrins are divided into the ephrin-A (EFNA) class,which are anchored to the membrane by aglycosylphosphatidylinositol linkage, and the ephrin-B (EFNB)class, which are transmembrane proteins. This gene encodes an EFNBclass ephrin which binds to the EPHB4 and EPHA3 receptors.


Zhang, R., et al. Psychiatry Res 180(1):5-9(2010)Bochenek, M.L., et al. J. Cell. Sci. 123 (PT 8), 1235-1246 (2010) :Nakada, M., et al. Int. J. Cancer 126(5):1155-1165(2010)Qin, H., et al. J. Biol. Chem. 285(1):644-654(2010)Kwan Tat, S., et al. Arthritis Res. Ther. 11 (4), R119 (2009) :

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$ 80.00
Cat# BP11652c
Availability: In Stock
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