|Other Names||D(1B) dopamine receptor, D(5) dopamine receptor, D1beta dopamine receptor, Dopamine D5 receptor, DRD5, DRD1B, DRD1L2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Neuron-specific, localized primarily within limbic regions of the brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the D5 subtype of the dopamine receptor.The D5 subtype is a G-protein coupled receptor which stimulatesadenylyl cyclase. This receptor is expressed in neurons in thelimbic regions of the brain. It has a 10-fold higher affinity fordopamine than the D1 subtype. Pseudogenes related to this genereside on chromosomes 1 and 2.
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)Muller, D.J., et al. Pharmacogenomics J. (2010) In press :Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Sloan, C.D., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1060-1069 (2010) :Marley, A., et al. PLoS ONE 5 (5), E10902 (2010) :
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