|Other Names||Cationic amino acid transporter 2, CAT-2, CAT2, Low affinity cationic amino acid transporter 2, Solute carrier family 7 member 2, SLC7A2, ATRC2, CAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) (PubMed:9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart|
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Provided below are standard protocols that you may find useful for product applications.
Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages (By similarity).
Chaturvedi, R., et al. Gastroenterology 139(5):1686-1698(2010)Visigalli, R., et al. J. Mol. Cell. Cardiol. 49(2):260-270(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :Jaeger, K., et al. Histochem. Cell Biol. 129(3):321-329(2008)Broer, S. Physiol. Rev. 88(1):249-286(2008)
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