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GFER Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P55789 |
|---|---|
| Clone Names | 71213114 |
| Gene ID | 2671 |
|---|---|
| Other Names | FAD-linked sulfhydryl oxidase ALR, Augmenter of liver regeneration, hERV1, Hepatopoietin, GFER, ALR, HERV1, HPO |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GFER |
|---|---|
| Synonyms | ALR, HERV1, HPO |
| Function | [Isoform 1]: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. |
| Cellular Location | [Isoform 1]: Mitochondrion intermembrane space. Mitochondrion |
| Tissue Location | Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of a phylogenetically conservedfamily of genes that share a common DNA-binding domain, the T-box.T-box genes encode transcription factors involved in the regulationof developmental processes. Knockout studies in mice indicate thatthis gene is important for specification of paraxial mesodermstructures.
References
Fei, Q., et al. Spine 35(9):983-988(2010)Ghebranious, N., et al. J. Bone Miner. Res. 23(10):1576-1583(2008)Farin, H.F., et al. J. Biol. Chem. 282(35):25748-25759(2007)Papapetrou, C., et al. Genomics 55(2):238-241(1999)Yi, C.H., et al. Genomics 55(1):10-20(1999)
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