|Other Names||FAD-linked sulfhydryl oxidase ALR, Augmenter of liver regeneration, hERV1, Hepatopoietin, GFER, ALR, HERV1, HPO|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ALR, HERV1, HPO|
|Function||Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.|
|Cellular Location||Isoform 1: Mitochondrion intermembrane space|
|Tissue Location||Ubiquitously expressed. Highest expression in the testis and liver and low expression in the muscle|
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This gene is a member of a phylogenetically conservedfamily of genes that share a common DNA-binding domain, the T-box.T-box genes encode transcription factors involved in the regulationof developmental processes. Knockout studies in mice indicate thatthis gene is important for specification of paraxial mesodermstructures.
Fei, Q., et al. Spine 35(9):983-988(2010)Ghebranious, N., et al. J. Bone Miner. Res. 23(10):1576-1583(2008)Farin, H.F., et al. J. Biol. Chem. 282(35):25748-25759(2007)Papapetrou, C., et al. Genomics 55(2):238-241(1999)Yi, C.H., et al. Genomics 55(1):10-20(1999)
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