|Other Names||Glypican-6, Secreted glypican-6, GPC6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cell surface proteoglycan that bears heparan sulfate. Putative cell surface coreceptor for growth factors, extracellular matrix proteins, proteases and anti-proteases (By similarity). Enhances migration and invasion of cancer cells through WNT5A signaling.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side|
|Tissue Location||Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).|
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This gene belongs to the Ras oncogene family, whosemembers are related to the transforming genes of mammalian sarcomaretroviruses. The products encoded by these genes function insignal transduction pathways. These proteins can bind GTP and GDP,and they have intrinsic GTPase activity. This protein undergoes acontinuous cycle of de- and re-palmitoylation, which regulates itsrapid exchange between the plasma membrane and the Golgi apparatus.Mutations in this gene cause Costello syndrome, a diseasecharacterized by increased growth at the prenatal stage, growthdeficiency at the postnatal stage, predisposition to tumorformation, mental retardation, skin and musculoskeletalabnormalities, distinctive facial appearance and cardiovascularabnormalities. Defects in this gene are implicated in a variety ofcancers, including bladder cancer, follicular thyroid cancer, andoral squamous cell carcinoma. Multiple transcript variants, whichencode different isoforms, have been identified for this gene.
Ma, Z., et al. Oncogene 29(41):5559-5567(2010)van Engen-van Grunsven, A.C., et al. Am. J. Surg. Pathol. 34(10):1436-1441(2010)Li, H., et al. Oncogene 29(36):5083-5094(2010)Kwack, K.B., et al. Korean J Gastroenterol 56(2):78-82(2010)Amosenko, F.A., et al. Genetika 46(5):700-708(2010)
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