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TBX6 Antibody (Center W158) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95947 |
|---|---|
| Clone Names | 71017107 |
| Gene ID | 6911 |
|---|---|
| Other Names | T-box transcription factor TBX6, T-box protein 6, TBX6 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TBX6 |
|---|---|
| Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia (By similarity). |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}. |
| Tissue Location | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the inhibitor of apoptosis (IAP)gene family, which encode negative regulatory proteins that preventapoptotic cell death. IAP family members usually contain multiplebaculovirus IAP repeat (BIR) domains, but this gene encodesproteins with only a single BIR domain. The encoded proteins alsolack a C-terminus RING finger domain. Gene expression is highduring fetal development and in most tumors yet low in adulttissues. Antisense transcripts are involved in the regulation ofthis gene's expression. At least four transcript variants encodingdistinct isoforms have been found for this gene, but thefull-length natures of only three of them have been determined.
References
Nabilsi, N.H., et al. J. Endocrinol. 207(2):237-243(2010)Valenzuela, M., et al. J. Infect. Dis. 202(7):1021-1030(2010)Yoon, S., et al. FEBS Lett. 584(18):4048-4052(2010)Ezponda, T., et al. Clin. Cancer Res. 16(16):4113-4125(2010)Sawai, K., et al. Oncol. Res. 18 (11-12), 541-547 (2010) :
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