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OTX2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P32243 |
|---|---|
| Clone Names | 80522082 |
| Gene ID | 5015 |
|---|---|
| Other Names | Homeobox protein OTX2, Orthodenticle homolog 2, OTX2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | OTX2 |
|---|---|
| Function | Transcription factor probably involved in the development of the brain and the sense organs. Can bind to the bicoid/BCD target sequence (BTS): 5'-TCTAATCCC-3'. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene uses alternative splicing to generate twodifferent proteins- high molecular weight kininogen (HMWK) and lowmolecular weight kininogen (LMWK). HMWK is essential for bloodcoagulation and assembly of the kallikrein-kinin system. Also,bradykinin, a peptide causing numerous physiological effects, isreleased from HMWK. In contrast to HMWK, LMWK is not involved inblood coagulation. Three transcript variants encoding differentisoforms have been found for this gene.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Houlihan, L.M., et al. Am. J. Hum. Genet. 86(4):626-631(2010)Khan, M.M., et al. Am. J. Physiol. Heart Circ. Physiol. 298 (2), H652-H658 (2010) :Bellucci, F., et al. Br. J. Pharmacol. 158(8):1996-2004(2009)
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