|Other Names||Homeobox protein OTX2, Orthodenticle homolog 2, OTX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
This gene uses alternative splicing to generate twodifferent proteins- high molecular weight kininogen (HMWK) and lowmolecular weight kininogen (LMWK). HMWK is essential for bloodcoagulation and assembly of the kallikrein-kinin system. Also,bradykinin, a peptide causing numerous physiological effects, isreleased from HMWK. In contrast to HMWK, LMWK is not involved inblood coagulation. Three transcript variants encoding differentisoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Houlihan, L.M., et al. Am. J. Hum. Genet. 86(4):626-631(2010)Khan, M.M., et al. Am. J. Physiol. Heart Circ. Physiol. 298 (2), H652-H658 (2010) :Bellucci, F., et al. Br. J. Pharmacol. 158(8):1996-2004(2009)
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