|Other Names||Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Inter-alpha-inhibitor heavy chain 1, Inter-alpha-trypsin inhibitor complex component III, Serum-derived hyaluronan-associated protein, SHAP, ITIH1, IGHEP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.|
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This gene is a member of the type IV, cyclic AMP(cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family.Cyclic nucleotides are important second messengers that regulateand mediate a number of cellular responses to extracellularsignals, such as hormones, light, and neurotransmitters. The cyclicnucleotide phosphodiesterases (PDEs) regulate the cellularconcentrations of cyclic nucleotides and thereby play a role insignal transduction. This gene encodes a protein that specificallyhydrolyzes cAMP. Altered activity of this protein has beenassociated with schizophrenia and bipolar affective disorder.Alternate transcriptional splice variants, encoding differentisoforms, have been characterized.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Souza, R.P., et al. Int Clin Psychopharmacol 25(5):264-269(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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