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> home > Products > Peptides > Biological Process > Metabolic Process > MLH1 Antibody (Center) Blocking Peptides
MLH1 Antibody (Center) Blocking PeptidesSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP11686c | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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MLH1 Antibody (Center) Blocking Peptides - Product info | |
| Primary Accession | P40692 |
| Clone Names | 80821077 |
| Calculated MW | 84601 Da |
MLH1 Antibody (Center) Blocking Peptides - Additional info | |
| Gene ID 4292 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
MLH1 Antibody (Center) Blocking Peptides - Protein Information | |
| Name MLH1 | |
| Synonyms COCA2 | |
| Function Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis | |
| Cellular Location Nucleus. | |
| Tissue Location Colon, lymphocytes, breast, lung, spleen, testis, prostate, thyroid, gall bladder and heart | |
MLH1 Antibody (Center) Blocking Peptides - Research Areas
PeptidesBiological ProcessMetabolic ProcessPrimary Metabolic ProcessCellular Metabolic ProcessCellular ProcessPositive Regulation Of Biological ProcessPositive Regulation Of Cellular ProcessRegulation Of Cell DeathRegulation Of Programmed Cell DeathRegulation Of ApoptosisNegative Regulation Of Cellular ProcessNegative Regulation Of Biological ProcessSystem DevelopmentMacromolecule Metabolic ProcessIntracellular Signaling CascadeMulticellular Organismal DevelopmentAnatomical Structure DevelopmentDevelopmental ProcessCellular Macromolecule Metabolic ProcessCatabolic ProcessPositive Regulation Of Cell DeathPositive Regulation Of ApoptosisPositive Regulation Of Programmed Cell DeathResponse To StressNegative Regulation Of Metabolic ProcessCellular Catabolic ProcessCellular Response To StimulusNegative Regulation Of Cellular Metabolic ProcessRegulation Of Metabolic ProcessMacromolecular Complex AssemblyCellular Component Organization
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BACKGROUND
This gene encodes a protein that may function in tumorsuppression. This protein binds to and colocalizes with the breastcancer 2 early onset protein (BRCA2) in nuclear foci and likelypermits the stable intranuclear localization and accumulation ofBRCA2.
REFERENCES
Dray, E., et al. Nat. Struct. Mol. Biol. 17(10):1255-1259(2010)Buisson, R., et al. Nat. Struct. Mol. Biol. 17(10):1247-1254(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Adank, M.A., et al. Pediatr Blood Cancer 55(4):742-744(2010)Guenard, F., et al. Genet Test Mol Biomarkers 14(4):515-526(2010)
