|Other Accession||NP_870998.2, NP_066007.1|
|Other Names||Periaxin, PRX, KIAA1620|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Seems to be required for maintenance of peripheral nerve myelin sheath. May have a role in axon-glial interactions, possibly by interacting with the cytoplasmic domains of integral membrane proteins such as myelin-associated glycoprotein in the periaxonal regions of the Schwann cell plasma membrane. May have a role in the early phases of myelin deposition.|
|Cellular Location||Nucleus. Isoform 2: Cytoplasm.|
|Tissue Location||Isoform 1 and isoform 2 are found in sciatic nerve and Schwann cells.|
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This gene encodes a protein involved in peripheral nervemyelin upkeep. The encoded protein contains 2 PDZ domains whichwere named after PSD95 (post synaptic density protein), DlgA(Drosophila disc large tumor suppressor), and ZO1 (a mammaliantight junction protein). Two alternatively spliced transcriptvariants have been described for this gene which encode differentprotein isoforms and which are targeted differently in the Schwanncell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy,type 4F and Dejerine-Sottas neuropathy.
Benson, B., et al. Laryngoscope 120(2):291-296(2010)Kabzinska, D., et al. Med Wieku Rozwoj 13(2):146-153(2009)Auer-Grumbach, M., et al. Neuropediatrics 39(1):33-38(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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