|Other Names||Autophagy-related protein 16-2, APG16-like 2, WD repeat-containing protein 80, ATG16L2, WDR80|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in autophagy.|
|Cellular Location||Cytoplasm. Note=Localizes also to discrete punctae along the ciliary axoneme.|
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The ADF (actin-depolymerizing factor)/cofilin family (seeMIM 601442) is composed of stimulus-responsive mediators of actindynamics. ADF/cofilin proteins are inactivated by kinases such asLIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears toplay a role in actin dynamics by reactivating ADF/cofilin proteinsin vivo (Niwa et al., 2002 [PubMed 11832213]).
Kousaka, K., et al. Genesis 46(5):246-255(2008)Kligys, K., et al. J. Biol. Chem. 282(44):32520-32528(2007)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Soosairajah, J., et al. EMBO J. 24(3):473-486(2005)Ohta, Y., et al. Genes Cells 8(10):811-824(2003)
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