QTRTD1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H974 |
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Clone Names | 80924151 |
Gene ID | 79691 |
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Other Names | Queuine tRNA-ribosyltransferase subunit QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043}, 24229 {ECO:0000255|HAMAP-Rule:MF_03043}, Queuine tRNA-ribosyltransferase domain-containing protein 1 {ECO:0000255|HAMAP-Rule:MF_03043}, QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | QTRT2 {ECO:0000255|HAMAP-Rule:MF_03043} |
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Synonyms | QTRTD1 |
Function | Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). |
Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane. {ECO:0000255|HAMAP- Rule:MF_03043} |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the Ras association domainfamily. It functions as a tumor suppressor, and is inactivated in avariety of cancers. The encoded protein localizes to centrosomesand microtubules, and associates with the GTP-activated forms ofRas, Rap1, and several other Ras-like small GTPases. The proteinregulates lymphocyte adhesion and suppresses cell growth inresponse to activated Rap1 or Ras. Multiple transcript variantsencoding different isoforms have been found for this gene.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Bee, C., et al. J. Biol. Chem. 285(21):16258-16266(2010)Raab, M., et al. Immunity 32(4):541-556(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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