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QTRTD1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9H974
Clone Names 80924151
Peptide ID 80924151
Additional Information
Gene ID 79691
Other Names Queuine tRNA-ribosyltransferase subunit QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043}, 24229 {ECO:0000255|HAMAP-Rule:MF_03043}, Queuine tRNA-ribosyltransferase domain-containing protein 1 {ECO:0000255|HAMAP-Rule:MF_03043}, QTRTD1 {ECO:0000255|HAMAP-Rule:MF_03043}
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name QTRT2 {ECO:0000255|HAMAP-Rule:MF_03043}
Synonyms QTRTD1
Function Non-catalytic subunit of the queuine tRNA- ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1- yl)amino)methyl)-7-deazaguanosine).
Cellular Location Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03043}. Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03043}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_03043}. Note=May associate with the mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03043}
Research Areas
Citations (0)

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Background

This gene is a member of the Ras association domainfamily. It functions as a tumor suppressor, and is inactivated in avariety of cancers. The encoded protein localizes to centrosomesand microtubules, and associates with the GTP-activated forms ofRas, Rap1, and several other Ras-like small GTPases. The proteinregulates lymphocyte adhesion and suppresses cell growth inresponse to activated Rap1 or Ras. Multiple transcript variantsencoding different isoforms have been found for this gene.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :Bee, C., et al. J. Biol. Chem. 285(21):16258-16266(2010)Raab, M., et al. Immunity 32(4):541-556(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)

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$ 80.00
Cat# BP11696b
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