|Other Names||Protocadherin beta-10, PCDH-beta-10, PCDHB10|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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This gene encodes glutamate dehydrogenase protein; amitochondrial matrix enzyme that catalyzes the oxidativedeamination of glutamate to alpha-ketoglutarate and ammonia. Thisenzyme has an important role in regulating amino acid inducedinsulin secretion and activating mutations in this gene are acommon cause of congenital hyperinsulinism. This enzyme isallosterically activated by ADP and inhibited by GTP and ATP. Therelated glutamate dehydrogenase 2 gene on the human X-chromosomeoriginated from this gene via retrotransposition and encodes asoluble form of glutamate dehydrogenase. Multiple pseudogenes ofthis gene are present in humans.
Martins-de-Souza, D., et al. J Psychiatr Res 44(14):989-991(2010)Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) :Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)Flanagan, S.E., et al. Eur. J. Endocrinol. 162(5):987-992(2010)Bao, X., et al. J. Neurosci. 29(44):13929-13944(2009)
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