|Other Names||Cell cycle checkpoint protein RAD17, hRad17, RF-C/activator 1 homolog, RAD17, R24L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.|
|Cellular Location||Nucleus. Note=Phosphorylated form redistributes to discrete nuclear foci upon DNA damage|
|Tissue Location||Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).|
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Provided below are standard protocols that you may find useful for product applications.
The OCT1 transcription factor was among the firstidentified members of the POU transcription factor family(summarized by Sturm et al., 1993 [PubMed 8314572]). Members ofthis family contain the POU domain, a 160-amino acid regionnecessary for DNA binding to the octameric sequenceATGCAAAT.
Vuzman, D., et al. Biophys. J. 99(4):1202-1211(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)Laurent, B., et al. Blood 115(3):687-695(2010)Becker, M.L., et al. Pharmacogenet. Genomics 20(1):38-44(2010)
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