|Other Names||POU domain, class 2, transcription factor 1, NF-A1, Octamer-binding protein 1, Oct-1, Octamer-binding transcription factor 1, OTF-1, POU2F1, OCT1, OTF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR (By similarity). In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.|
|Tissue Location||Ubiquitous. Isoform 2 is lymphocyte-specific.|
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This gene encodes a member of the paired box (PAX) familyof transcription factors. The central feature of this gene familyis a novel, highly conserved DNA-binding motif, known as the pairedbox. PAX proteins are important regulators in early development,and alterations in the expression of their genes are thought tocontribute to neoplastic transformation. This gene encodes theB-cell lineage specific activator protein that is expressed atearly, but not late stages of B-cell differentiation. Itsexpression has also been detected in developing CNS and testis andso the encoded protein may also play a role in neural developmentand spermatogenesis. This gene is located at 9p13, which isinvolved in t(9;14)(p13;q32) translocations recurring in smalllymphocytic lymphomas of the plasmacytoid subtype, and in derivedlarge-cell lymphomas. This translocation brings the potent E-muenhancer of the IgH gene into close proximity of the PAX5 promoter,suggesting that the deregulation of transcription of this genecontributes to the pathogenesis of these lymphomas. Alternativelyspliced transcript variants encoding different isoforms have beendescribed but their biological validity has not been determined.
Song, J., et al. Arch. Pathol. Lab. Med. 134(11):1702-1705(2010)Okamoto, R., et al. Haematologica 95(9):1481-1488(2010)Best, A., et al. Leuk. Res. 34(8):1098-1102(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Vidal, L.J., et al. Mol. Cancer Res. 8(3):444-456(2010)
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