|Other Names||Group XV phospholipase A2, 231-, 1-O-acylceramide synthase, ACS, LCAT-like lysophospholipase, LLPL, Lysophospholipase 3, Lysosomal phospholipase A2, LPLA2, PLA2G15, LYPLA3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has transacylase and calcium-independent phospholipase A2 activity (PubMed:20410020, PubMed:23958596). Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:25727495). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3- phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl- sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (By similarity). May have weak lysophospholipase activity (PubMed:10092508).|
|Cellular Location||Lysosome. Secreted. Membrane; Peripheral membrane protein|
|Tissue Location||Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508).|
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The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains an extracellulardomain, a single transmembrane segment and two tandemintracytoplasmic catalytic domains, and thus belongs to receptortype PTP. This gene is specifically expressed in hematopoieticcells. This PTP has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through eitherdirect interaction with components of the antigen receptorcomplexes, or by activating various Src family kinases required forthe antigen receptor signaling. This PTP also suppresses JAKkinases, and thus functions as a regulator of cytokine receptorsignaling. Four alternatively spliced transcripts variants of thisgene, which encode distinct isoforms, have been reported. [providedby RefSeq].
Heyd, F., et al. Mol. Cell 40(1):126-137(2010)Wu, Z., et al. J. Immunol. 185(1):231-238(2010)Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010)Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010)Capitanescu, B., et al. Rom J Morphol Embryol 51(1):49-54(2010)
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