LYPLA3 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NCC3 |
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Clone Names | 81202093 |
Gene ID | 23659 |
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Other Names | Group XV phospholipase A2, 231-, 1-O-acylceramide synthase, ACS, LCAT-like lysophospholipase, LLPL, Lysophospholipase 3, Lysosomal phospholipase A2, LPLA2, PLA2G15, LYPLA3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PLA2G15 (HGNC:17163) |
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Synonyms | LYPLA3 |
Function | Has dual calcium-independent phospholipase and O- acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:10092508, PubMed:11790796, PubMed:20410020, PubMed:23958596, PubMed:29724779, PubMed:25727495). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines (PubMed:29724779). Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines and phosphatidylethanolamines (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide (PubMed:29724779). Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (PubMed:30830753). Required for normal phospholipid degradation in alveolar macrophages with potential implications in pulmonary surfactant clearance (By similarity). At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (PubMed:10092508). |
Cellular Location | Lysosome. Secreted. Membrane; Peripheral membrane protein |
Tissue Location | Detected in blood plasma (at protein level) (PubMed:10092508, PubMed:20410020). Ubiquitous. Highly expressed in heart, placenta, skeletal muscle, kidney and pancreas. Detected at lower levels in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes (PubMed:10092508) |
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Background
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. This PTP contains an extracellulardomain, a single transmembrane segment and two tandemintracytoplasmic catalytic domains, and thus belongs to receptortype PTP. This gene is specifically expressed in hematopoieticcells. This PTP has been shown to be an essential regulator of T-and B-cell antigen receptor signaling. It functions through eitherdirect interaction with components of the antigen receptorcomplexes, or by activating various Src family kinases required forthe antigen receptor signaling. This PTP also suppresses JAKkinases, and thus functions as a regulator of cytokine receptorsignaling. Four alternatively spliced transcripts variants of thisgene, which encode distinct isoforms, have been reported. [providedby RefSeq].
References
Heyd, F., et al. Mol. Cell 40(1):126-137(2010)Wu, Z., et al. J. Immunol. 185(1):231-238(2010)Cui, J., et al. Arthritis Rheum. 62(7):1849-1861(2010)Booth, N.J., et al. J. Immunol. 184(8):4317-4326(2010)Capitanescu, B., et al. Rom J Morphol Embryol 51(1):49-54(2010)
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