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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   PTPRC Antibody (N-term) Blocking peptide   

PTPRC Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P08575
Clone Names 81205024
Peptide ID 81205024
Additional Information
Gene ID 5788
Other Names Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, CD45, PTPRC, CD45
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CD45
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Research Areas
Citations (0)

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Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor-and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity).


Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Aude-Garcia, C., et al. Biochem. J. 430(2):237-244(2010)Czubryt, M.P., et al. J. Biol. Chem. 285(22):16942-16950(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)

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$ 80.00
Cat# BP11708a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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