|Other Names||Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single- stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'- UTR, possibly by recruiting degradation machinery to ARE- containing mRNAs.|
|Cellular Location||Nucleus. Cytoplasm. Note=A small proportion is also found in the cytoplasm of neuronal cell bodies and dendrites.|
|Tissue Location||Detected in neural and non-neural cell lines.|
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This gene is a member of the Antp homeobox family andencodes a protein with a homeobox DNA-binding domain. It isincluded in a cluster of homeobox B genes located on chromosome 17.The encoded protein functions as a sequence-specific transcriptionfactor that is involved in development, including that of lung andskin, and has been localized to both the nucleus and cytoplasm.Altered expression of this gene or a change in the subcellularlocalization of its protein is associated with some cases of acutemyeloid leukemia and colorectal cancer.
Ferrai, C., et al. Mol. Biol. Cell 20(15):3543-3551(2009)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chen, T., et al. Eur. J. Hum. Genet. 15(1):23-28(2007)Shen, W., et al. J. Biol. Chem. 279(38):39895-39904(2004)
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