|Other Names||Serine protease 55, 3421-, Testis serine protease 1, T-SP1, PRSS55, TSP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable serine protease.|
|Cellular Location||Isoform 1: Membrane; Single- pass type I membrane protein|
|Tissue Location||Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells. Expressed in prostate cancer and ovarian cancer (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)Yeung, M.L., et al. Cancer Res. 68(21):8976-8985(2008)Daniele, B. J. Clin. Gastroenterol. 42(4):336-337(2008)Sawaya, M., et al. J. Clin. Gastroenterol. 42(4):351-355(2008)Bernardo, M.V., et al. Biochem. Biophys. Res. Commun. 359(2):317-322(2007)
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