UNQ9391 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6UWB4 |
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Clone Names | 100203039 |
Gene ID | 203074 |
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Other Names | Serine protease 55, 3421-, Testis serine protease 1, T-SP1, PRSS55, TSP1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | PRSS55 |
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Synonyms | TSP1 {ECO:0000303|PubMed:18844450} |
Function | Probable serine protease, which plays a crucial role in the fertility of male mice including sperm migration and sperm-egg interaction. |
Cellular Location | [Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q14BX2}. Cytoplasm, cytosol. Note=Mainly found in the membrane part of the cells and only in small amounts in the cytosol |
Tissue Location | Only detected in testis. Expressed in spermatogonia, spermatocytes, spermatids, Leydig and Sertoli cells Expressed in prostate cancer and ovarian cancer (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis.
References
Voight, B.F., et al. Nat. Genet. 42(7):579-589(2010)Yeung, M.L., et al. Cancer Res. 68(21):8976-8985(2008)Daniele, B. J. Clin. Gastroenterol. 42(4):336-337(2008)Sawaya, M., et al. J. Clin. Gastroenterol. 42(4):351-355(2008)Bernardo, M.V., et al. Biochem. Biophys. Res. Commun. 359(2):317-322(2007)
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