|Other Accession||NP_149083.2, NP_149084.2, NP_149023.2|
|Other Names||Tripartite motif-containing protein 5, 632-, RING finger protein 88, TRIM5, RNF88|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF- kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equine infectious anemia virus (EIAV).|
|Cellular Location||Cytoplasm, P-body Note=Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies.|
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Provided below are standard protocols that you may find useful for product applications.
C2orf57 is an uncharacterized protein.
Ohmine, S., et al. J. Biol. Chem. 285(45):34508-34517(2010)Battivelli, E., et al. J. Virol. 84(21):11010-11019(2010)Malbec, M., et al. Virology 405(2):414-423(2010)Price, H., et al. AIDS 24(12):1813-1821(2010)Kuroishi, A., et al. Retrovirology 7, 58 (2010) :
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