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EXD1 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NHP7
Other Accession NP_689809.2
Clone Names 100309074
Additional Information
Gene ID 161829
Other Names Exonuclease 3'-5' domain-containing protein 1, Exonuclease 3'-5' domain-like-containing protein 1, EXD1, EXDL1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EXD1
Synonyms EXDL1
Function RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity (By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:H9IUR0}. Note=Component of the meiotic nuage, also named P granule, a germ-cell- specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:H9IUR0}
Research Areas
Citations (0)
citation

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References

Hillier, L.W., et al. Nature 424(6945):157-164(2003)

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$ 277.78
Cat# BP11751b
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