|Other Names||Low-density lipoprotein receptor-related protein 12, LRP-12, Suppressor of tumorigenicity 7 protein, LRP12, ST7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor.|
|Cellular Location||Membrane; Single-pass type I membrane protein Membrane, coated pit|
|Tissue Location||Widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas, but not in tissues consisting of a large number of epithelial cells, such as liver and kidney Expressed at very low levels in a number of tumor-derived cell lines.|
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ARHJ belongs to the Rho family of small GTP-bindingproteins. Rho proteins regulate the dynamic assembly ofcytoskeletal components for several physiologic processes, such ascell proliferation and motility and the establishment of cellpolarity. They are also involved in pathophysiologic process, suchas cell transformation and metastasis.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)Nishikimi, A., et al. FEBS Lett. 579(5):1039-1046(2005)Ruusala, A., et al. FEBS Lett. 572 (1-3), 159-166 (2004) :
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