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RHOJ Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9H4E5 |
|---|---|
| Other Accession | NP_065714.1 |
| Clone Names | 101008235 |
| Gene ID | 57381 |
|---|---|
| Other Names | Rho-related GTP-binding protein RhoJ, Ras-like protein family member 7B, Tc10-like GTP-binding protein, RHOJ, ARHJ, RASL7B, RHOI, TCL |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RHOJ |
|---|---|
| Function | Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). |
| Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side Note=Localization to the plasma membrane is regulated by GLUL |
| Tissue Location | Specifically expressed in endothelial cells in different tissues, such as brain, heart, lung and liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ARHJ belongs to the Rho family of small GTP-bindingproteins. Rho proteins regulate the dynamic assembly ofcytoskeletal components for several physiologic processes, such ascell proliferation and motility and the establishment of cellpolarity. They are also involved in pathophysiologic process, suchas cell transformation and metastasis.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Lamesch, P., et al. Genomics 89(3):307-315(2007)Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)Nishikimi, A., et al. FEBS Lett. 579(5):1039-1046(2005)Ruusala, A., et al. FEBS Lett. 572 (1-3), 159-166 (2004) :
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