MIC1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96DM3 |
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Clone Names | 71211134 |
Gene ID | 29919 |
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Other Names | Uncharacterized protein C18orf8, Colon cancer-associated protein Mic1, Mic-1, C18orf8, MIC1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RMC1 (HGNC:24326) |
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Synonyms | C18orf8, MIC1, WDR98 |
Function | Componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). Acts as a positive regulator of CCZ1-MON1A/B function necessary for endosomal/autophagic flux and efficient RAB7A localization (PubMed:29038162). |
Cellular Location | Lysosome membrane. Late endosome membrane |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the Rho GTPase family, whosemembers play a key role in the regulation of actin cytoskeletonorganization in response to extracellular growth factors. Thisparticular family member has been implicated in the regulation ofneuronal morphology and endosomal trafficking. The gene localizesto chromosome 17 and is the centromeric neighbor of thebreast-ovarian cancer susceptibility gene BRCA1. [provided byRefSeq].
References
Tanaka, H., et al. J. Biol. Chem. 281(15):10355-10364(2006)Kim, Y.S., et al. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. 142(4):410-415(2005)Kakimoto, T., et al. J. Biol. Chem. 279(14):14104-14110(2004)Naud, N., et al. Biochem. J. 372 (PT 1), 105-112 (2003) :Fujita, H., et al. J. Biol. Chem. 277(47):45428-45434(2002)
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