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NBN Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O60934
Clone Names 80722054
Peptide ID 80722054
Additional Information
Gene ID 4683
Other Names Nibrin, Cell cycle regulatory protein p95, Nijmegen breakage syndrome protein 1, NBN, NBS, NBS1, P95
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name NBN
Synonyms NBS, NBS1, P95
Function Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1/MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection. Enhances AKT1 phosphorylation possibly by association with the mTORC2 complex.
Cellular Location Nucleus. Nucleus, PML body Chromosome, telomere. Note=Localizes to discrete nuclear foci after treatment with genotoxic agents.
Tissue Location Ubiquitous. Expressed at high levels in testis
Research Areas
Citations (0)

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The protein encoded by this intronless gene belongs to thehighly variable methyltransferase superfamily. This gene is theinferred homolog of the Saccharomyces cerevisiaecarboxymethyltransferase gene PPM2 that is essential for thesynthesis of the hypermodified guanosine Wybutosine (yW). [providedby RefSeq].


Noma, A., et al. EMBO J. 25(10):2142-2154(2006)De Baere, I., et al. Biochemistry 38(50):16539-16547(1999)

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$ 80.00
Cat# BP11776b
(40 western blots)
Availability: In Stock
Bulk Size
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