|Other Names||tRNA wybutosine-synthesizing protein 4, tRNA yW-synthesizing protein 4, Leucine carboxyl methyltransferase 2, tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-methoxycarbonyltransferase, tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-O)-methyltransferase, LCMT2, KIAA0547, TYW4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha- leucine ester residues.|
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This gene is a member of the Nod1/Apaf-1 family andencodes a protein with two caspase recruitment (CARD) domains andsix leucine-rich repeats (LRRs). The protein is primarily expressedin the peripheral blood leukocytes. It plays a role in the immuneresponse to intracellular bacterial lipopolysaccharides (LPS) byrecognizing the muramyl dipeptide (MDP) derived from them andactivating the NFKB protein. Mutations in this gene have beenassociated with Crohn disease and Blau syndrome. [provided byRefSeq].
Sehgal, R., et al. Dis. Colon Rectum 53(11):1487-1494(2010)Cadwell, K. Gastroenterology 139(5):1448-1450(2010)Lacher, M., et al. J. Pediatr. Surg. 45(8):1591-1597(2010)Kramer, M., et al. BMC Res Notes 3, 224 (2010) :Kanazawa, N., et al. Blood 105(3):1195-1197(2005)
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