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AGBL5 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8NDL9
Clone Names 81006003
Additional Information
Gene ID 60509
Other Names Cytosolic carboxypeptidase-like protein 5, 3417-, ATP/GTP-binding protein-like 5, AGBL5, CCP5
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name AGBL5 (HGNC:26147)
Function Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta- tubulin. Cleaves alpha- and gamma-linked polyglutamate tubulin side- chain, as well as the branching point glutamate. Also catalyzes the removal of alpha-linked glutamate residues from the carboxy-terminus of alpha-tubulin. Mediates deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation.
Cellular Location Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09M02}. Nucleus Cytoplasm, cytoskeleton, spindle. Midbody. Note=Mainly cytoplasmic. Slight accumulation in the nucleus is observed (By similarity). Colocalizes with alpha-tubulin in the mitotic spindle and with midbody microtubules in the intercellular bridges formed during cytokinesis {ECO:0000250|UniProtKB:Q09M02, ECO:0000269|PubMed:23085998}
Tissue Location Expressed in brain.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the nucleoporin family. Theprotein is localized to the nuclear rim and is an essentialcomponent of the nuclear pore complex (NPC). All molecules enteringor leaving the nucleus either diffuse through or are activelytransported by the NPC. Alternate transcriptional splice variantsof this gene have been observed but have not been thoroughlycharacterized.

References

Kim, S.Y., et al. Biochem. Biophys. Res. Commun. 401(1):131-136(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Mishra, R.K., et al. Nat. Cell Biol. 12(2):164-169(2010)Platani, M., et al. Mol. Biol. Cell 20(24):5260-5275(2009)Whittle, J.R., et al. J. Biol. Chem. 284(41):28442-28452(2009)

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$ 277.78
Cat# BP11785a
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