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PURA Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q00577 |
|---|---|
| Clone Names | 81110014 |
| Gene ID | 5813 |
|---|---|
| Other Names | Transcriptional activator protein Pur-alpha, Purine-rich single-stranded DNA-binding protein alpha, PURA, PUR1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PURA |
|---|---|
| Synonyms | PUR1 |
| Function | This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts with signalingpathways to coordinately regulate cell growth, cell proliferation,apoptosis, autophagy, and cell migration. This tumor suppressoralso enhances retinoblastoma 1 gene expression in cancer cells.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
References
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Chano, T., et al. PLoS ONE 5 (6), E11404 (2010) :Paun, B.C., et al. PLoS ONE 4 (11), E7715 (2009) :Chan, E.Y. Sci Signal 2 (84), PE51 (2009) :
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