|Other Names||Transcriptional activator protein Pur-alpha, Purine-rich single-stranded DNA-binding protein alpha, PURA, PUR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.|
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The protein encoded by this gene interacts with signalingpathways to coordinately regulate cell growth, cell proliferation,apoptosis, autophagy, and cell migration. This tumor suppressoralso enhances retinoblastoma 1 gene expression in cancer cells.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Chano, T., et al. PLoS ONE 5 (6), E11404 (2010) :Paun, B.C., et al. PLoS ONE 4 (11), E7715 (2009) :Chan, E.Y. Sci Signal 2 (84), PE51 (2009) :
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