|Other Names||Transcriptional activator protein Pur-alpha, Purine-rich single-stranded DNA-binding protein alpha, PURA, PUR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||This is a probable transcription activator that specifically binds the purine-rich single strand of the PUR element located upstream of the MYC gene. May play a role in the initiation of DNA replication and in recombination.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene interacts with signalingpathways to coordinately regulate cell growth, cell proliferation,apoptosis, autophagy, and cell migration. This tumor suppressoralso enhances retinoblastoma 1 gene expression in cancer cells.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010)Chano, T., et al. PLoS ONE 5 (6), E11404 (2010) :Paun, B.C., et al. PLoS ONE 4 (11), E7715 (2009) :Chan, E.Y. Sci Signal 2 (84), PE51 (2009) :
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