|Other Accession||NP_055596.3, NP_001077086.1|
|Other Names||RB1-inducible coiled-coil protein 1, FAK family kinase-interacting protein of 200 kDa, FIP200, RB1CC1, KIAA0203, RBICC|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a modulator of TGF-beta-signaling by restricting substrate specificity of RNF111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis (By similarity). Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways.|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Preautophagosomal structure membrane; Peripheral membrane protein Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.|
|Tissue Location||Expression levels correlated closely with those of RB1 in cancer cell lines as well as in various normal human tissues. Abundantly expressed in human musculoskeletal and cultured osteosarcoma cells.|
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The protein encoded by this gene interacts with signalingpathways to coordinately regulate cell growth, cell proliferation,apoptosis, autophagy, and cell migration. This tumor suppressoralso enhances retinoblastoma 1 gene expression in cancer cells.Alternative splicing results in multiple transcript variantsencoding distinct isoforms.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Fellay, J., et al. PLoS Genet. 5 (12), E1000791 (2009) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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