|Other Names||Uncharacterized protein C11orf21, C11orf21|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed exclusively in heart.|
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The product of this gene belongs to the family ofclassical tyrosine-specific protein tyrosine phosphatases. Manyprotein tyrosine phosphatases have been shown to regulatefundamental cellular processes and several are mutated in humandiseases. Chromosome 10q contains a segmental duplication resultingin multiple copies of the protein tyrosine phosphatase,non-receptor type 20 gene. The two nearly identical copies aredesignated as PTPN20A and PTPN20B. A third copy is only partiallyduplicated and contains a pseudogene, designated as PTPN20C. Thisgene encodes the more telomeric copy, PTPN20B. Multiplealternatively spliced transcript variants encoding differentisoforms have been identified.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Fodero-Tavoletti, M.T., et al. Biochem. J. 389 (PT 2), 343-354 (2005) :
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