|Other Names||Uncharacterized protein C11orf21, C11orf21|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Expressed exclusively in heart. EMBL; AB029488; BAA89482.1; -; mRNA EMBL; AC129929; -; NOT_ANNOTATED_CDS; Genomic_DNA RefSeq; NP_001136418.1; NM_001142946.2 RefSeq; NP_001316887.1; NM_001329958.1 UniGene; Hs.559181; - ProteinModelPortal; Q9P2W6; - PaxDb; Q9P2W6; - PRIDE; Q9P2W6; - ProteomicsDB; 83904; - Ensembl; ENST00000381153; ENSP00000370545; ENSG00000110665 GeneID; 29125; - KEGG; hsa:29125; - UCSC; uc001lvv.3; human CTD; 29125; - DisGeNET; 29125; - EuPathDB; HostDB:ENSG00000110665.11; - GeneCards; C11orf21; - H-InvDB; HIX0035817; - HGNC; HGNC:13231; C11orf21 HPA; HPA037607; - MIM; 611033; gene neXtProt; NX_Q9P2W6; - OpenTargets; ENSG00000110665; - PharmGKB; PA25486; - eggNOG; ENOG410KFY1; Eukaryota eggNOG; ENOG4110SVT; LUCA GeneTree; ENSGT00390000000843; - HOGENOM; HOG000111721; - HOVERGEN; HBG050974; - InParanoid; Q9P2W6; - GenomeRNAi; 29125; - PRO; PR:Q9P2W6; - Proteomes; UP000005640; Chromosome 11 Bgee; ENSG00000110665; - CleanEx; HS_C11orf21; - ExpressionAtlas; Q9P2W6; baseline and differential Genevisible; Q9P2W6; HS GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell InterPro; IPR027894; DUF4620 Pfam; PF15399; DUF4620; 1 2: Evidence at transcript level; Complete proteome; Cytoplasm; Reference proteome CHAIN 1 132 Uncharacterized protein C11orf21 /FTId=PRO_0000089834 SEQUENCE 132 AA; 14447 MW; 3D8A2246EC0A7683 CRC64; MGRTWCGMWR RRRPGRRSAV PRWPHLSSQS GVEPPDRWTG TPGWPSRDQE APGSMMPPAA AQPSAHGALV PPATAHEPVD HPALHWLACC CCLSLPGQLP LAIRLGWDLD LEAGPSSGKL CPRARRWQPL PS|
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The product of this gene belongs to the family ofclassical tyrosine-specific protein tyrosine phosphatases. Manyprotein tyrosine phosphatases have been shown to regulatefundamental cellular processes and several are mutated in humandiseases. Chromosome 10q contains a segmental duplication resultingin multiple copies of the protein tyrosine phosphatase,non-receptor type 20 gene. The two nearly identical copies aredesignated as PTPN20A and PTPN20B. A third copy is only partiallyduplicated and contains a pseudogene, designated as PTPN20C. Thisgene encodes the more telomeric copy, PTPN20B. Multiplealternatively spliced transcript variants encoding differentisoforms have been identified.
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Fodero-Tavoletti, M.T., et al. Biochem. J. 389 (PT 2), 343-354 (2005) :
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