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ARL5C Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | A6NH57 |
|---|---|
| Clone Names | 100203290 |
| Gene ID | 390790 |
|---|---|
| Other Names | Putative ADP-ribosylation factor-like protein 5C, ADP-ribosylation factor-like protein 12, ARL5C, ARL12 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ARL5C |
|---|---|
| Synonyms | ARL12 |
| Function | Binds and exchanges GTP and GDP. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the NOD (nucleotide-bindingoligomerization domain) family. This member is a cytosolic protein.It contains an N-terminal caspase recruitment domain (CARD), acentrally located nucleotide-binding domain (NBD), and 10 tandemleucine-rich repeats (LRRs) in its C terminus. The CARD is involvedin apoptotic signaling, LRRs participate in protein-proteininteractions, and mutations in the NBD may affect the process ofoligomerization and subsequent function of the LRR domain. Thisprotein is an intracellular pattern-recognition receptor (PRR) thatinitiates inflammation in response to a subset of bacteria throughthe detection of bacterial diaminopimelic acid. Multiplealternatively spliced transcript variants differring in the 5' UTRhave been described, but the full-length nature of these variantshas not been determined.
References
Hutton, M.L., et al. Infect. Immun. 78(11):4523-4531(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lu, W.G., et al. World J. Gastroenterol. 16(34):4348-4356(2010)Enevold, C., et al. Mult. Scler. 16(8):942-949(2010)Ashton, K.A., et al. BMC Cancer 10, 382 (2010) :
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