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LRWD1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9UFC0
Other Accession NP_690852.1
Clone Names 100120272
Peptide ID 100120272
Additional Information
Gene ID 222229
Other Names Leucine-rich repeat and WD repeat-containing protein 1, Centromere protein 33, CENP-33, Origin recognition complex-associated protein, ORC-associated protein, ORCA, LRWD1, CENP33, ORCA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name LRWD1
Synonyms CENP33, ORCA
Function Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability.
Cellular Location Nucleus. Chromosome, centromere. Chromosome, telomere. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localizes to heterochromatin during G1 phase. Restricted to centromeres or telomeres as cells progress though S phase. When cells enter mitosis, relocalizes to centromeres. Recruitment to pericentric heterochromatin largely depends on the presence of H3K9me3
Tissue Location Testis-specific. Drastically down-regulated in testis from patients with Sertoli cell-only syndrome (SCOS)
Research Areas
Citations (0)

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LRWD1, Leucine rich repeats and WD repeat domain containing 1, contains 3 LRR (leucine-rich) repeats and 5 WD repeats.


Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :

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$ 80.00
Cat# BP11807a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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