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CBLN2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8IUK8
Other Accession NP_872317.1
Clone Names 91201164
Peptide ID 91201164
Additional Information
Other Names Cerebellin-2, CBLN2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBLN2
Function May play role in synaptogenesis induction.
Cellular Location Secreted. EMBL; AK291364; BAF84053.1; -; mRNA EMBL; AY359074; AAQ89433.1; -; mRNA EMBL; CH471117; EAW66527.1; -; Genomic_DNA EMBL; BC035789; AAH35789.1; -; mRNA CCDS; CCDS11999.1; - RefSeq; NP_872317.1; NM_182511.3 RefSeq; XP_006722457.1; XM_006722394.3 RefSeq; XP_011524126.1; XM_011525824.2 RefSeq; XP_016881048.1; XM_017025559.1 RefSeq; XP_016881049.1; XM_017025560.1 UniGene; Hs.569851; - ProteinModelPortal; Q8IUK8; - SMR; Q8IUK8; - STRING; 9606.ENSP00000269503; - iPTMnet; Q8IUK8; - PhosphoSitePlus; Q8IUK8; - BioMuta; CBLN2; - DMDM; 46395886; - EPD; Q8IUK8; - PaxDb; Q8IUK8; - PeptideAtlas; Q8IUK8; - PRIDE; Q8IUK8; - ProteomicsDB; 70583; - Ensembl; ENST00000269503; ENSP00000269503; ENSG00000141668 Ensembl; ENST00000585159; ENSP00000463771; ENSG00000141668 GeneID; 147381; - KEGG; hsa:147381; - UCSC; uc002lku.4; human CTD; 147381; - DisGeNET; 147381; - EuPathDB; HostDB:ENSG00000141668.9; - GeneCards; CBLN2; - HGNC; HGNC:1544; CBLN2 MIM; 600433; gene neXtProt; NX_Q8IUK8; - OpenTargets; ENSG00000141668; - Orphanet; 275777; Heritable pulmonary arterial hypertension Orphanet; 275766; Idiopathic pulmonary arterial hypertension PharmGKB; PA26119; - eggNOG; ENOG410IFXA; Eukaryota eggNOG; ENOG410Y16R; LUCA GeneTree; ENSGT00760000119052; - HOGENOM; HOG000085657; - HOVERGEN; HBG108329; - InParanoid; Q8IUK8; - OMA; QVNLMQN; - OrthoDB; EOG091G0XK2; - PhylomeDB; Q8IUK8; - TreeFam; TF329591; - GenomeRNAi; 147381; - PRO; PR:Q8IUK8; - Proteomes; UP000005640; Chromosome 18 Bgee; ENSG00000141668; - CleanEx; HS_CBLN2; - ExpressionAtlas; Q8IUK8; baseline and differential Genevisible; Q8IUK8; HS GO; GO:0005615; C:extracellular space; IEA:Ensembl GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl Gene3D; 2.60.120.40; -; 1 InterPro; IPR001073; C1q_dom InterPro; IPR008983; Tumour_necrosis_fac-like_dom Pfam; PF00386; C1q; 1 PRINTS; PR00007; COMPLEMNTC1Q SMART; SM00110; C1Q; 1 SUPFAM; SSF49842; SSF49842; 1 PROSITE; PS50871; C1Q; 1 2: Evidence at transcript level; Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal SIGNAL 1 51 CHAIN 52 224 Cerebellin-2 /FTId=PRO_0000003551 DOMAIN 88 224 C1q. {ECO:0000255|PROSITE- ProRule:PRU00368} CARBOHYD 53 53 N-linked (GlcNAc...) asparagine CARBOHYD 110 110 N-linked (GlcNAc...) asparagine SEQUENCE 224 AA; 24084 MW; A08C8BB3D686A9C5 CRC64; MQAPGRGPLG LRLMMPGRRG ALREPGGCGS CLGVALALLL LLLPACCPVR AQNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL KLERGNLMGG WKYSTFSGFL VFPL
Research Areas
Citations (0)

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Background

WTIP may monitor slit diaphragm protein assembly, a specialized adherens junction characteristic of podocytes. In case of podocyte injury, it shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype (By similarity).

References

Grant, S.F., et al. J. Pediatr. 155(6):909-913(2009)Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)Kavety, B., et al. Brain Res. Mol. Brain Res. 27(1):152-156(1994)

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$ 80.00
Cat# BP11835b
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